Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
ada2b_human | 448 | C-term | T => Leu | frameshift | 7.185e-05 | 7 | 97430 | 0 | None | None | ||
ada2b_human | 442 | 8.59x59 | H8 | C => Ter | stop gained | 3.663e-05 | 4 | 109206 | 0 | None | None | |
ada2b_human | 427 | 7.54x54 | TM7 | T => ThrfsTer140 | frameshift | 8.564e-06 | 1 | 116772 | 0 | None | None | |
ada2b_human | 379 | 6.43x43 | TM6 | V => ProfsTer40 | frameshift | 8.652e-06 | 1 | 115576 | 0 | None | None | |
ada2b_human | 378 | 6.42x42 | TM6 | G => GlyfsTer41 | frameshift | 8.659e-06 | 1 | 115492 | 0 | None | None | |
ada2b_human | 376 | 6.40x40 | TM6 | V => SerfsTer165 | frameshift | 8.654e-06 | 1 | 115550 | 0 | None | None | GP (contact) |
ada2b_human | 366 | 6.30x30 | TM6 | E => ArgfsTer172 | frameshift | 8.696e-06 | 1 | 115000 | 0 | None | None | SodiumPocket MicroSwitch |
ada2b_human | 356 | ICL3 | W => Ter | stop gained | 3.77e-05 | 4 | 106108 | 0 | None | None | ||
ada2b_human | 348 | ICL3 | G => Ter | frameshift | 1.062e-05 | 1 | 94204 | 0 | None | None | ||
ada2b_human | 297 | ICL3 | A => GlyfsTer11 | frameshift | 0.0001124 | 5 | 44486 | 0 | None | None | ||
ada2b_human | 295 | ICL3 | D => GlufsTer54 | frameshift | 8.111e-05 | 4 | 49316 | 0 | None | None | ||
ada2b_human | 220 | ICL3 | Q => Ter | stop gained | 1.686e-05 | 2 | 118612 | 0 | None | None | ||
ada2b_human | 208 | 5.74x74 | TM5 | R => GlyfsTer142 | frameshift | 1.676e-05 | 2 | 119360 | 0 | None | None | GP (contact) |
ada2b_human | 157 | ECL2 | Q => Ter | stop gained | 8.423e-06 | 1 | 118728 | 0 | None | None | ||
ada2b_human | 104 | 3.44x44 | TM3 | C => Ter | stop gained | 8.599e-06 | 1 | 116286 | 0 | None | None | |
ada2b_human | 98 | 3.38x38 | TM3 | S => Ter | stop gained | 0.0001117 | 13 | 116390 | 1 | None | None | |
ada2b_human | 65 | 2.57x56 | TM2 | I => SerfsTer50 | frameshift | 8.515e-06 | 1 | 117434 | 0 | None | None | |
ada2b_human | 445 | C-term | W => M | missense | 0.0005522 | 58 | 105032 | 0 | nan | 0.185 | ||
ada2b_human | 445 | C-term | W => K | missense | 4.76e-05 | 5 | 105032 | 0 | nan | 0.769 | ||
ada2b_human | 441 | 8.58x58 | H8 | L => L | missense | 2.705e-05 | 3 | 110922 | 0 | nan | 0.032 | |
ada2b_human | 440 | 8.57x57 | H8 | I => H | missense | 8.947e-06 | 1 | 111774 | 0 | nan | 0.846 | |
ada2b_human | 440 | 8.57x57 | H8 | I => C | missense | 4.451e-05 | 5 | 112338 | 0 | nan | 0.918 | |
ada2b_human | 435 | 8.52x52 | H8 | R => Q | missense | 5.22e-05 | 6 | 114950 | 0 | nan | 0.493 | |
ada2b_human | 435 | 8.52x52 | H8 | R => W | missense | 6.074e-05 | 7 | 115236 | 0 | nan | 0.764 | |
ada2b_human | 433 | 8.50x50 | H8 | F => P | missense | 8.637e-06 | 1 | 115784 | 0 | nan | 0.956 | |
ada2b_human | 433 | 8.50x50 | H8 | F => T | missense | 1.727e-05 | 2 | 115784 | 0 | nan | 0.511 | |
ada2b_human | 432 | 8.49x49 | H8 | D => H | missense | 8.627e-06 | 1 | 115916 | 0 | nan | 0.099 | GP (contact) |
ada2b_human | 432 | 8.49x49 | H8 | D => C | missense | 4.308e-05 | 5 | 116068 | 0 | nan | 0.78 | GP (contact) |
ada2b_human | 431 | 8.48x48 | H8 | Q => H | missense | 8.61e-06 | 1 | 116138 | 0 | nan | 0.336 | GP (contact) |
ada2b_human | 431 | 8.48x48 | H8 | Q => C | missense | 4.3e-05 | 5 | 116272 | 0 | nan | 0.992 | GP (contact) |
ada2b_human | 429 | 7.56x56 | TM7 | F => H | missense | 8.57e-06 | 1 | 116688 | 0 | nan | 0.967 | GP (contact) |
ada2b_human | 420 | 7.47x47 | TM7 | S => S | missense | 8.53e-06 | 1 | 117236 | 0 | nan | 1.0 | |
ada2b_human | 417 | 7.44x43 | TM7 | C => L | missense | 8.54e-06 | 1 | 117098 | 0 | nan | 0.02 | SodiumPocket MicroSwitch |
ada2b_human | 415 | 7.42x41 | TM7 | G => H | missense | 8.586e-06 | 1 | 116474 | 0 | nan | 0.999 | LB (Van der Waals) |
ada2b_human | 413 | 7.40x39 | TM7 | W => C | missense | 3.393e-05 | 4 | 117902 | 0 | nan | 1.0 | |
ada2b_human | 412 | 7.39x38 | TM7 | F => S | missense | 4.246e-05 | 5 | 117750 | 0 | nan | 1.0 | LB (polar (hydrogen bond with backbone), Van der Waals, hydrophobic) |
ada2b_human | 411 | 7.38x37 | TM7 | F => V | missense | 9.339e-05 | 11 | 117780 | 0 | nan | 0.316 | |
ada2b_human | 409 | 7.36x35 | TM7 | Q => S | missense | 1.7e-05 | 2 | 117670 | 0 | nan | 0.971 | |
ada2b_human | 399 | ECL3 | K => R | missense | 5.986e-05 | 7 | 116946 | 0 | nan | 0.008 | ||
ada2b_human | 395 | 6.59x59 | TM6 | A => L | missense | 1.718e-05 | 2 | 116388 | 0 | nan | 0.884 | |
ada2b_human | 394 | 6.58x58 | TM6 | G => G | missense | 8.564e-06 | 1 | 116768 | 0 | nan | 0.996 | |
ada2b_human | 389 | 6.53x53 | TM6 | F => R | missense | 1.726e-05 | 2 | 115876 | 0 | nan | 0.984 | |
ada2b_human | 383 | 6.47x47 | TM6 | C => A | missense | 8.657e-06 | 1 | 115510 | 0 | nan | 1.0 | |
ada2b_human | 382 | 6.46x46 | TM6 | L => L | missense | 1.73e-05 | 2 | 115590 | 0 | nan | 0.042 | |
ada2b_human | 380 | 6.44x44 | TM6 | F => Y | missense | 5.193e-05 | 6 | 115550 | 0 | nan | 0.998 | SodiumPocket MicroSwitch |
ada2b_human | 376 | 6.40x40 | TM6 | V => G | missense | 0.0001471 | 17 | 115602 | 0 | nan | 0.786 | GP (contact) |
ada2b_human | 376 | 6.40x40 | TM6 | V => I | missense | 0.002181 | 252 | 115550 | 0 | nan | 0.771 | GP (contact) |
ada2b_human | 374 | 6.38x38 | TM6 | A => T | missense | 8.647e-06 | 1 | 115644 | 0 | nan | 0.196 | |
ada2b_human | 374 | 6.38x38 | TM6 | A => S | missense | 8.647e-06 | 1 | 115644 | 0 | nan | 0.802 | |
ada2b_human | 369 | 6.33x33 | TM6 | F => L | missense | 8.686e-06 | 1 | 115126 | 0 | nan | 0.902 | GP (contact) |
ada2b_human | 367 | 6.31x31 | TM6 | K => I | missense | 1.745e-05 | 2 | 114624 | 0 | nan | 0.985 | |
ada2b_human | 366 | 6.30x30 | TM6 | E => C | missense | 8.748e-06 | 1 | 114308 | 0 | nan | 0.991 | SodiumPocket MicroSwitch |
ada2b_human | 365 | 6.29x29 | TM6 | R => C | missense | 1.762e-05 | 2 | 113510 | 0 | nan | 1.0 | GP (contact) |
ada2b_human | 362 | 6.26x26 | TM6 | Q => Q | missense | 1.778e-05 | 2 | 112474 | 0 | nan | 0.992 | GP (contact) |
ada2b_human | 362 | 6.26x26 | TM6 | Q => W | missense | 0.0002316 | 26 | 112276 | 1 | nan | 0.999 | GP (contact) |
ada2b_human | 361 | 6.25x25 | TM6 | A => S | missense | 8.93e-06 | 1 | 111982 | 0 | nan | 0.004 | GP (contact) |
ada2b_human | 357 | ICL3 | W => Q | missense | 8.376e-05 | 9 | 107446 | 0 | nan | 0.814 | ||
ada2b_human | 357 | ICL3 | W => W | missense | 9.336e-06 | 1 | 107110 | 0 | nan | 0.198 | ||
ada2b_human | 355 | ICL3 | Q => H | missense | 0.0005806 | 61 | 105062 | 0 | nan | 0.954 | ||
ada2b_human | 355 | ICL3 | Q => P | missense | 1.904e-05 | 2 | 105062 | 0 | nan | 0.964 | ||
ada2b_human | 355 | ICL3 | Q => C | missense | 8.667e-05 | 9 | 103840 | 0 | nan | 0.302 | ||
ada2b_human | 354 | ICL3 | G => C | missense | 1.947e-05 | 2 | 102736 | 0 | nan | 0.99 | ||
ada2b_human | 351 | ICL3 | A => R | missense | 1.016e-05 | 1 | 98406 | 0 | nan | 0.107 | ||
ada2b_human | 346 | ICL3 | G => M | missense | 0.0001881 | 17 | 90362 | 0 | nan | 0.016 | ||
ada2b_human | 337 | ICL3 | A => H | missense | 2.934e-05 | 2 | 68168 | 0 | nan | 0.063 | ||
ada2b_human | 337 | ICL3 | A => C | missense | 5.908e-05 | 4 | 67704 | 0 | nan | 0.944 | ||
ada2b_human | 331 | ICL3 | Q => L | missense | 2.017e-05 | 1 | 49588 | 0 | nan | 0.313 | ||
ada2b_human | 331 | ICL3 | Q => Q | missense | 2.017e-05 | 1 | 49588 | 0 | nan | 0.013 | ||
ada2b_human | 331 | ICL3 | Q => W | missense | 2.052e-05 | 1 | 48730 | 0 | nan | 0.828 | ||
ada2b_human | 323 | ICL3 | C => R | missense | 2.887e-05 | 1 | 34634 | 0 | nan | 0.022 | ||
ada2b_human | 323 | ICL3 | C => T | missense | 8.635e-05 | 3 | 34744 | 0 | nan | 0.012 | ||
ada2b_human | 316 | ICL3 | P => L | missense | 3.238e-05 | 1 | 30888 | 0 | nan | 0.031 | ||
ada2b_human | 312 | ICL3 | P => M | missense | 0.0005292 | 15 | 28344 | 0 | nan | 0.009 | ||
ada2b_human | 309 | ICL3 | E => S | missense | 0.0003346 | 8 | 23910 | 0 | nan | 0.098 | ||
ada2b_human | 290 | ICL3 | G => E | missense | 2.213e-05 | 1 | 45190 | 0 | nan | 0.011 | ||
ada2b_human | 284 | ICL3 | Q => H | missense | 1.908e-05 | 1 | 52406 | 0 | nan | 0.019 | ||
ada2b_human | 281 | ICL3 | G => V | missense | 3.313e-05 | 2 | 60362 | 0 | nan | 0.047 | ||
ada2b_human | 277 | ICL3 | L => F | missense | 1.375e-05 | 1 | 72746 | 0 | nan | 0.012 | ||
ada2b_human | 269 | ICL3 | A => S | missense | 9.976e-06 | 1 | 100240 | 0 | nan | 0.007 | ||
ada2b_human | 268 | ICL3 | R => W | missense | 4.849e-05 | 5 | 103122 | 0 | nan | 0.005 | ||
ada2b_human | 266 | ICL3 | G => E | missense | 3.769e-05 | 4 | 106138 | 0 | nan | 0.007 | ||
ada2b_human | 263 | ICL3 | E => K | missense | 0.0002105 | 23 | 109250 | 0 | nan | 0.03 | ||
ada2b_human | 253 | ICL3 | T => A | missense | 8.753e-05 | 10 | 114242 | 0 | nan | 0.002 | ||
ada2b_human | 252 | ICL3 | S => T | missense | 8.735e-06 | 1 | 114486 | 0 | nan | 0.003 | ||
ada2b_human | 250 | ICL3 | S => L | missense | 6.957e-05 | 8 | 114994 | 0 | nan | 0.008 | ||
ada2b_human | 244 | ICL3 | R => I | missense | 1.723e-05 | 2 | 116088 | 0 | nan | 0.023 | ||
ada2b_human | 244 | ICL3 | R => G | missense | 1.723e-05 | 2 | 116108 | 0 | nan | 0.0 | ||
ada2b_human | 239 | ICL3 | S => F | missense | 8.563e-06 | 1 | 116776 | 0 | nan | 0.031 | ||
ada2b_human | 236 | ICL3 | A => V | missense | 8.543e-06 | 1 | 117054 | 0 | nan | 0.038 | ||
ada2b_human | 236 | ICL3 | A => D | missense | 1.709e-05 | 2 | 117054 | 0 | nan | 0.006 | ||
ada2b_human | 230 | ICL3 | A => P | missense | 8.502e-06 | 1 | 117622 | 0 | nan | 0.012 | ||
ada2b_human | 229 | ICL3 | L => S | missense | 4.248e-05 | 5 | 117710 | 0 | nan | 0.001 | ||
ada2b_human | 226 | ICL3 | G => V | missense | 2.545e-05 | 3 | 117882 | 0 | nan | 0.005 | ||
ada2b_human | 224 | ICL3 | D => E | missense | 8.475e-06 | 1 | 117988 | 0 | nan | 0.002 | ||
ada2b_human | 224 | ICL3 | D => N | missense | 8.476e-06 | 1 | 117984 | 0 | nan | 0.001 | ||
ada2b_human | 223 | ICL3 | P => R | missense | 8.462e-06 | 1 | 118174 | 0 | nan | 0.003 | ||
ada2b_human | 223 | ICL3 | P => L | missense | 8.462e-06 | 1 | 118174 | 0 | nan | 0.003 | ||
ada2b_human | 222 | ICL3 | R => Q | missense | 8.459e-06 | 1 | 118214 | 0 | nan | 0.003 | ||
ada2b_human | 222 | ICL3 | R => P | missense | 8.459e-06 | 1 | 118214 | 0 | nan | 0.003 | ||
ada2b_human | 221 | ICL3 | P => S | missense | 8.435e-06 | 1 | 118556 | 0 | nan | 0.008 | ||
ada2b_human | 220 | ICL3 | Q => H | missense | 8.434e-06 | 1 | 118570 | 0 | nan | 0.669 | ||
ada2b_human | 217 | ICL3 | E => K | missense | 3.367e-05 | 4 | 118808 | 0 | nan | 0.003 | ||
ada2b_human | 217 | ICL3 | E => Q | missense | 8.417e-06 | 1 | 118808 | 0 | nan | 0.02 | ||
ada2b_human | 212 | ICL3 | G => A | missense | 8.405e-06 | 1 | 118974 | 0 | nan | 0.005 | ||
ada2b_human | 212 | ICL3 | G => V | missense | 8.405e-06 | 1 | 118974 | 0 | nan | 0.008 | ||
ada2b_human | 211 | ICL3 | G => A | missense | 0.03618 | 4312 | 119196 | 102 | nan | 0.003 | ||
ada2b_human | 211 | ICL3 | G => V | missense | 8.39e-06 | 1 | 119196 | 0 | nan | 0.088 | ||
ada2b_human | 210 | ICL3 | K => N | missense | 1.677e-05 | 2 | 119268 | 0 | nan | 0.012 | ||
ada2b_human | 210 | ICL3 | K => M | missense | 1.677e-05 | 2 | 119246 | 0 | nan | 0.126 | ||
ada2b_human | 210 | ICL3 | K => E | missense | 1.676e-05 | 2 | 119300 | 0 | nan | 0.038 | ||
ada2b_human | 206 | 5.72x72 | TM5 | G => D | missense | 8.37e-06 | 1 | 119478 | 0 | nan | 0.438 | GP (contact) |
ada2b_human | 205 | 5.71x71 | TM5 | R => T | missense | 8.37e-06 | 1 | 119480 | 0 | nan | 0.096 | GP (contact) |
ada2b_human | 205 | 5.71x71 | TM5 | R => I | missense | 8.37e-06 | 1 | 119480 | 0 | nan | 0.096 | GP (contact) |
ada2b_human | 203 | 5.69x69 | TM5 | N => K | missense | 8.36e-06 | 1 | 119616 | 0 | nan | 0.001 | GP (contact) |
ada2b_human | 197 | 5.63x63 | TM5 | L => Q | missense | 8.346e-06 | 1 | 119820 | 0 | nan | 0.209 | |
ada2b_human | 194 | 5.60x60 | TM5 | R => H | missense | 1.668e-05 | 2 | 119886 | 0 | nan | 0.993 | |
ada2b_human | 194 | 5.60x60 | TM5 | R => S | missense | 8.341e-06 | 1 | 119896 | 0 | nan | 0.903 | |
ada2b_human | 190 | 5.56x56 | TM5 | L => F | missense | 1.667e-05 | 2 | 119978 | 0 | nan | 0.71 | |
ada2b_human | 188 | 5.54x54 | TM5 | M => L | missense | 8.333e-06 | 1 | 120004 | 0 | nan | 0.645 | |
ada2b_human | 187 | 5.53x53 | TM5 | I => M | missense | 0.0001333 | 16 | 120002 | 0 | nan | 0.997 | |
ada2b_human | 186 | 5.52x52 | TM5 | L => F | missense | 8.333e-06 | 1 | 120012 | 0 | nan | 0.274 | |
ada2b_human | 179 | 5.45x46 | TM5 | G => V | missense | 8.339e-06 | 1 | 119920 | 0 | nan | 0.628 | |
ada2b_human | 179 | 5.45x46 | TM5 | G => R | missense | 8.34e-06 | 1 | 119908 | 0 | nan | 0.961 | |
ada2b_human | 178 | 5.44x45 | TM5 | I => V | missense | 8.34e-06 | 1 | 119910 | 0 | nan | 0.012 | |
ada2b_human | 171 | 5.37x38 | TM5 | W => C | missense | 3.341e-05 | 4 | 119718 | 0 | nan | 0.991 | |
ada2b_human | 170 | 5.36x37 | TM5 | A => V | missense | 0.0002173 | 26 | 119648 | 0 | nan | 0.042 | |
ada2b_human | 164 | 45.50x50 | ECL2 | C => Y | missense | 8.381e-06 | 1 | 119316 | 0 | nan | 1.0 | |
ada2b_human | 164 | 45.50x50 | ECL2 | C => R | missense | 1.677e-05 | 2 | 119288 | 0 | nan | 1.0 | |
ada2b_human | 160 | ECL2 | G => E | missense | 8.402e-06 | 1 | 119024 | 0 | nan | 0.037 | ||
ada2b_human | 160 | ECL2 | G => R | missense | 6.727e-05 | 8 | 118930 | 0 | nan | 0.656 | ||
ada2b_human | 159 | ECL2 | R => L | missense | 2.523e-05 | 3 | 118924 | 0 | nan | 0.005 | ||
ada2b_human | 159 | ECL2 | R => C | missense | 1.683e-05 | 2 | 118866 | 0 | nan | 0.017 | ||
ada2b_human | 158 | ECL2 | P => L | missense | 8.412e-06 | 1 | 118872 | 0 | nan | 0.03 | ||
ada2b_human | 155 | ECL2 | G => S | missense | 8.429e-06 | 1 | 118636 | 0 | nan | 0.008 | ||
ada2b_human | 153 | ECL2 | D => Y | missense | 8.437e-06 | 1 | 118520 | 0 | nan | 0.737 | ||
ada2b_human | 146 | 4.59x59 | TM4 | P => Q | missense | 8.463e-06 | 1 | 118162 | 0 | nan | 0.999 | |
ada2b_human | 135 | 4.48x48 | TM4 | T => I | missense | 8.484e-06 | 1 | 117874 | 0 | nan | 0.008 | |
ada2b_human | 133 | 4.46x46 | TM4 | I => N | missense | 8.482e-06 | 1 | 117902 | 0 | nan | 0.999 | |
ada2b_human | 128 | 4.41x41 | TM4 | R => P | missense | 8.523e-06 | 1 | 117336 | 0 | nan | 0.999 | |
ada2b_human | 128 | 4.41x41 | TM4 | R => S | missense | 0.0001704 | 20 | 117382 | 1 | nan | 0.998 | |
ada2b_human | 128 | 4.41x41 | TM4 | R => C | missense | 4.26e-05 | 5 | 117382 | 0 | nan | 1.0 | |
ada2b_human | 126 | 4.39x39 | TM4 | P => L | missense | 8.531e-06 | 1 | 117216 | 0 | nan | 0.716 | |
ada2b_human | 121 | 34.54x54 | ICL2 | N => S | missense | 8.541e-06 | 1 | 117084 | 0 | nan | 0.049 | GP (contact) |
ada2b_human | 118 | 34.51x51 | ICL2 | L => V | missense | 2.566e-05 | 3 | 116906 | 0 | nan | 0.036 | GP (contact) |
ada2b_human | 116 | 3.56x56 | TM3 | R => L | missense | 8.563e-06 | 1 | 116776 | 0 | nan | 0.66 | GP (contact) |
ada2b_human | 116 | 3.56x56 | TM3 | R => H | missense | 8.563e-06 | 1 | 116776 | 0 | nan | 0.422 | GP (contact) |
ada2b_human | 114 | 3.54x54 | TM3 | V => M | missense | 4.286e-05 | 5 | 116670 | 0 | nan | 0.998 | GP (contact) |
ada2b_human | 112 | 3.52x52 | TM3 | W => R | missense | 8.559e-06 | 1 | 116838 | 0 | nan | 0.885 | |
ada2b_human | 111 | 3.51x51 | TM3 | Y => C | missense | 8.558e-06 | 1 | 116852 | 0 | nan | 0.994 | |
ada2b_human | 110 | 3.50x50 | TM3 | R => P | missense | 8.57e-06 | 1 | 116680 | 0 | nan | 1.0 | SodiumPocket MicroSwitch GP (contact) |
ada2b_human | 110 | 3.50x50 | TM3 | R => C | missense | 8.569e-06 | 1 | 116696 | 0 | nan | 1.0 | SodiumPocket MicroSwitch GP (contact) |
ada2b_human | 105 | 3.45x45 | TM3 | A => T | missense | 0.0002918 | 34 | 116524 | 1 | nan | 0.996 | |
ada2b_human | 105 | 3.45x45 | TM3 | A => S | missense | 8.582e-06 | 1 | 116524 | 0 | nan | 0.997 | |
ada2b_human | 88 | 3.28x28 | TM3 | Y => H | missense | 8.612e-06 | 1 | 116114 | 0 | nan | 0.8 | |
ada2b_human | 86 | 3.26x26 | TM3 | E => D | missense | 8.619e-06 | 1 | 116022 | 0 | nan | 0.047 | |
ada2b_human | 86 | 3.26x26 | TM3 | E => K | missense | 8.624e-06 | 1 | 115962 | 0 | nan | 0.027 | |
ada2b_human | 83 | 3.23x23 | TM3 | T => M | missense | 8.609e-06 | 1 | 116156 | 0 | nan | 0.063 | |
ada2b_human | 81 | 3.21x21 | TM3 | R => Q | missense | 8.594e-06 | 1 | 116354 | 0 | nan | 0.022 | |
ada2b_human | 81 | 3.21x21 | TM3 | R => P | missense | 8.594e-06 | 1 | 116354 | 0 | nan | 0.65 | |
ada2b_human | 72 | 2.64x63 | TM2 | N => K | missense | 8.543e-06 | 1 | 117054 | 0 | nan | 0.933 | |
ada2b_human | 68 | 2.60x59 | TM2 | F => I | missense | 0.0001107 | 13 | 117446 | 0 | nan | 0.924 | |
ada2b_human | 59 | 2.51x51 | TM2 | I => S | missense | 0.0001539 | 18 | 116936 | 0 | nan | 0.952 | |
ada2b_human | 58 | 2.50x50 | TM2 | D => G | missense | 8.577e-06 | 1 | 116596 | 0 | nan | 0.999 | |
ada2b_human | 56 | 2.48x48 | TM2 | A => T | missense | 2.577e-05 | 3 | 116402 | 0 | nan | 0.967 | |
ada2b_human | 50 | 2.42x42 | TM2 | F => L | missense | 8.606e-06 | 1 | 116192 | 0 | nan | 0.8 | |
ada2b_human | 46 | 2.38x38 | TM2 | P => A | missense | 8.683e-06 | 1 | 115162 | 0 | nan | 0.922 | |
ada2b_human | 45 | 2.37x37 | TM2 | A => V | missense | 8.698e-06 | 1 | 114974 | 0 | nan | 0.86 | |
ada2b_human | 44 | 12.51x51 | ICL1 | R => C | missense | 8.75e-05 | 10 | 114288 | 0 | nan | 0.927 | |
ada2b_human | 42 | 12.49x49 | ICL1 | S => P | missense | 8.79e-06 | 1 | 113772 | 0 | nan | 0.067 | |
ada2b_human | 32 | 1.52x52 | TM1 | L => V | missense | 9.143e-06 | 1 | 109370 | 0 | nan | 0.996 | |
ada2b_human | 31 | 1.51x51 | TM1 | A => G | missense | 9.145e-06 | 1 | 109348 | 0 | nan | 0.034 | |
ada2b_human | 29 | 1.49x49 | TM1 | G => C | missense | 9.257e-06 | 1 | 108030 | 0 | nan | 1.0 | |
ada2b_human | 21 | 1.41x41 | TM1 | F => V | missense | 9.631e-06 | 1 | 103834 | 0 | nan | 0.971 | |
ada2b_human | 19 | 1.39x39 | TM1 | I => N | missense | 9.77e-06 | 1 | 102354 | 0 | nan | 0.671 | |
ada2b_human | 18 | 1.38x38 | TM1 | A => T | missense | 9.783e-06 | 1 | 102220 | 0 | nan | 0.007 | |
ada2b_human | 12 | 1.32x32 | TM1 | T => K | missense | 3.094e-05 | 3 | 96964 | 0 | nan | 0.784 | |
ada2b_human | 8 | N-term | S => Y | missense | 1.088e-05 | 1 | 91874 | 0 | nan | 0.974 | ||
ada2b_human | 8 | N-term | S => F | missense | 1.088e-05 | 1 | 91874 | 0 | nan | 0.974 | ||
ada2b_human | 6 | N-term | P => T | missense | 1.148e-05 | 1 | 87126 | 0 | nan | 0.926 | ||
ada2b_human | 2 | N-term | D => N | missense | 2.424e-05 | 2 | 82508 | 0 | nan | 0.401 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue